The Role of the P2X7 Receptor in Infectious Diseases

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Show simple item record Miller, Catherine en_US Boulter, Nicola en_US Fuller, Stephen en_US Zakrzewski, Alana en_US Lees, Michael en_US Saunders, Bernadette en_US Wiley, James en_US Smith, Nicholas en_US
dc.contributor.editor en_US 2012-10-12T03:33:23Z 2012-10-12T03:33:23Z 2011 en_US
dc.identifier 2011004525 en_US
dc.identifier.citation Miller Catherine et al. 2011, 'The Role of the P2X7 Receptor in Infectious Diseases', Plos, vol. 7, no. 11, pp. e1002212-1-e1002212-7. en_US
dc.identifier.issn 1553-7366 en_US
dc.identifier.other C1 en_US
dc.description.abstract ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X7 receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X7 receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1? and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion. The P2X7 receptor can initiate host mechanisms to remove pathogens, most particularly those that parasitise macrophages. At the same time, the P2X7 receptor may be subverted by pathogens to modulate host responses. Moreover, recent genetic studies have demonstrated significant associations between susceptibility or resistance to parasites and bacteria, and loss-of-function or gain-of-function polymorphisms in the P2X7 receptor, underscoring its importance in infectious disease. en_US
dc.language en_US
dc.publisher Plos en_US
dc.title The Role of the P2X7 Receptor in Infectious Diseases en_US
dc.parent Plos Pathogens en_US
dc.journal.volume 7 en_US
dc.journal.number 11 en_US
dc.publocation USA en_US
dc.identifier.startpage e1002212-1 en_US
dc.identifier.endpage e1002212-7 en_US SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 970043 en_US
dc.personcode 011172 en_US
dc.personcode 0000020556 en_US
dc.personcode 100992 en_US
dc.personcode 044579 en_US
dc.personcode 0000081397 en_US
dc.personcode 0000020554 en_US
dc.personcode 960087 en_US
dc.percentage 34 en_US Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords en_US
dc.staffid 960087 en_US

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