Synthesis of stemofoline analogues as acetylcholinesterase inhibitors

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dc.contributor.author Sastraruji, Kwankamol en_US
dc.contributor.author Sastraruji, Thanapat en_US
dc.contributor.author Ung, Alison en_US
dc.contributor.author Griffith, Renate en_US
dc.contributor.author Jatisatienr, Araya en_US
dc.contributor.author Pyne, Stephen en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-10-12T03:33:00Z
dc.date.available 2012-10-12T03:33:00Z
dc.date.issued 2012 en_US
dc.identifier 2011004603 en_US
dc.identifier.citation Sastraruji Kwankamol et al. 2012, 'Synthesis of stemofoline analogues as acetylcholinesterase inhibitors', Elsevier Inc, vol. 68, no. 35, pp. 7103-7115. en_US
dc.identifier.issn 0040-4020 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/17989
dc.description.abstract Thirty-two new stemofoline analogues were prepared from didehydrostemofoline for studies as AChE inhibitors. C-3 Side-chain modified amino, carbamate, triazole and oxazole stemofoline derivatives were prepared. In general the amine derivatives were found to be stronger inhibitors of AChE than their alcohol analogues that we previously reported. Compounds 5 and 26, with small C-3 side-chain substituents, were two of the most active inhibitors. Preliminary molecular docking studies suggested that these compounds may inhibit AChE by binding horizontally along the passage of the active-site gorge and block access to acetylcholine. en_US
dc.language en_US
dc.publisher Elsevier Inc en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/j.tet.2012.06.047 en_US
dc.title Synthesis of stemofoline analogues as acetylcholinesterase inhibitors en_US
dc.parent Tetrahedron en_US
dc.journal.volume 68 en_US
dc.journal.number 35 en_US
dc.publocation United Kingdom en_US
dc.identifier.startpage 7103 en_US
dc.identifier.endpage 7115 en_US
dc.cauo.name SCI.School of Chemistry and Forensic Science en_US
dc.conference Verified OK en_US
dc.for 030400 en_US
dc.personcode 0000050290 en_US
dc.personcode 0000050250 en_US
dc.personcode 106546 en_US
dc.personcode 0000081487 en_US
dc.personcode 0000050251 en_US
dc.personcode 0000061573 en_US
dc.percentage 50 en_US
dc.classification.name Medicinal and Biomolecular Chemistry en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords ALZHEIMERS-DISEASE; ALDEHYDES; SEMISYNTHESIS; ALKALOIDS en_US
dc.staffid en_US


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