Transcription-targeted gene therapy for androgen-independent prostate cancer

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Transcription-targeted gene therapy for androgen-independent prostate cancer

Martiniello-Wilks Rosetta; Tsatralis Tania; Russell P; Brookes Diana; Zandvliet D; Lockett Lj; Both Gw; Molloy Pl; Russell Pj
URI: http://hdl.handle.net/10453/17074
Date: 2002

Abstract:

The Escherichia coli enzyme (purine nucleoside phosphorylase, PNP) gene is delivered directly into PC3 tumors by one injection of replication-deficient human type-5 adenovirus (Ad5). Expressed PNP converts the systemically administered prodrug, 6MPDR, to

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