Aminopeptidases of malaria parasites: New targets for chemotherapy.

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dc.contributor.author Trenholme, Katharine en_US
dc.contributor.author Brown, Christopher en_US
dc.contributor.author Skinner-Adams, Tina en_US
dc.contributor.author Stack, Colin en_US
dc.contributor.author Lowther, Jonathan en_US
dc.contributor.author To, Joyce en_US
dc.contributor.author Robinson, Mark en_US
dc.contributor.author Donnelly, Sheila en_US
dc.contributor.author Dalton, John en_US
dc.contributor.author Gardiner, Donald en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-02-10T06:09:13Z
dc.date.available 2012-02-10T06:09:13Z
dc.date.issued 2010 en_US
dc.identifier 2009005072 en_US
dc.identifier.citation Trenholme Katharine et al. 2010, 'Aminopeptidases of malaria parasites: New targets for chemotherapy.', Bentham Science Publishers Ltd, vol. 10, no. 3, pp. 217-225. en_US
dc.identifier.issn 1871-5265 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/16951
dc.description.abstract Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria, Plasmodium falciparum, that may have the potential to become new targets for antimalarial drug development are the aminopeptidases. These enzymes catalyse the cleavage of the N-terminal amino acids from proteins and peptides. P. falciparum appears to encode for at least nine aminopeptidases, two neutral aminopeptidases, one aspartyl aminopeptidase, one aminopeptidase P, one prolyl aminopeptidase and four methionine aminopeptidases. Recent advances in our understanding of these genes and their protein products are outlined in this review, including their potential for antimalarial drug development en_US
dc.language en_US
dc.publisher Bentham Science Publishers Ltd en_US
dc.title Aminopeptidases of malaria parasites: New targets for chemotherapy. en_US
dc.parent Infectious Disorders Drug Targets en_US
dc.journal.volume 10 en_US
dc.journal.number 3 en_US
dc.publocation U.A.E en_US
dc.identifier.startpage 217 en_US
dc.identifier.endpage 225 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 0000022368 en_US
dc.personcode 0000062050 en_US
dc.personcode 0000027738 en_US
dc.personcode 995262 en_US
dc.personcode 996591 en_US
dc.personcode 030199 en_US
dc.personcode 100777 en_US
dc.personcode 995261 en_US
dc.personcode 030896 en_US
dc.personcode 0000022367 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords aminopeptidase drug discovery malaria Plasmodium falciparum en_US


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