Chasing the golden egg: Vaccination against poultry coccidiosis

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dc.contributor.author Sharman, Philippa en_US
dc.contributor.author Smith, Nicholas en_US
dc.contributor.author Wallach, Michael en_US
dc.contributor.author Katrib, Marilyn en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-02-02T08:39:46Z
dc.date.available 2012-02-02T08:39:46Z
dc.date.issued 2010 en_US
dc.identifier 2011000580 en_US
dc.identifier.citation Sharman Philippa et al. 2010, 'Chasing the golden egg: Vaccination against poultry coccidiosis', Blackwell, vol. 32, no. 8, pp. 590-598. en_US
dc.identifier.issn 0141-9838 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/15023
dc.description.abstract P>Eimeria species, of the Phylum Apicomplexa, cause the disease coccidiosis in poultry, resulting in severe economic losses every year. Transmission of the disease is via the faecal-oral route, and is facilitated by intensive rearing conditions in the poultry industry. Additionally, Eimeria has developed drug resistance against most anticoccidials used today, which, along with the public demand for chemical free meat, has lead to the requirement for an effective vaccine strategy. This review focuses on the history and current status of anticoccidial vaccines, and our work in developing the transmission-blocking vaccine, CoxAbic (R) (Netanya, Israel). The vaccine is composed of affinity-purified antigens from the wall-forming bodies of macrogametocytes of Eimeria maxima, which are proteolytically processed and cross-linked via tyrosine residues to form the environmentally resistant oocyst wall. The vaccine is delivered via maternal immunization, where vaccination of laying hens leads to protection of broiler offspring. It has been extensively tested for efficacy and safety in field trials conducted in five countries and involving over 60 million offspring chickens from immunized hens and is currently the only subunit vaccine against any protozoan parasite to reach the marketplace. en_US
dc.language en_US
dc.publisher Blackwell en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1365-3024.2010.01209.x en_US
dc.title Chasing the golden egg: Vaccination against poultry coccidiosis en_US
dc.parent Parasite Immunology en_US
dc.journal.volume 32 en_US
dc.journal.number 8 en_US
dc.publocation UK en_US
dc.identifier.startpage 590 en_US
dc.identifier.endpage 598 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 070700 en_US
dc.personcode 10303600 en_US
dc.personcode 960087 en_US
dc.personcode 021128 en_US
dc.personcode 044726 en_US
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Apicomplexa; Eimeria; macrogamete; oocyst wall; vaccine; wall-forming bodies en_US
dc.staffid en_US
dc.staffid 044726 en_US


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