A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Hutvagner Gyorgy; Mclachlan J; Pasquinelli Ae; Balint E; Tuschl T; Zamore Pd
URI: http://hdl.handle.net/10453/14989
Date: 2001

Abstract:

The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated prec

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