Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study

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dc.contributor.author Ingold, Ana en_US
dc.contributor.author Vanegas-Gomez, Natasha en_US
dc.contributor.author Martinez Diaz, Maria en_US
dc.contributor.author Merlino, John en_US
dc.contributor.author Merkier, Andrea en_US
dc.contributor.author Castro, Mercedes en_US
dc.contributor.author Rocha, Gerardo en_US
dc.contributor.author Borthagaray, Graciela en_US
dc.contributor.author Centron, Daniela en_US
dc.contributor.author Toledo, Helia en_US
dc.contributor.author Marquez, Carolina en_US
dc.contributor.author Stokes, Hatch en_US
dc.contributor.author Roy Chowdhury, Piklu en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-02-02T08:21:22Z
dc.date.available 2012-02-02T08:21:22Z
dc.date.issued 2011 en_US
dc.identifier 2010003539 en_US
dc.identifier.citation Roy Chowdhury Piklu et al. 2011, 'Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study', American Society for Microbiology, vol. 55, no. 7, pp. 3140-3149. en_US
dc.identifier.issn 0066-4804 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/14987
dc.description.abstract A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum -lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy. en_US
dc.language en_US
dc.publisher American Society for Microbiology en_US
dc.relation.isbasedon http://dx.doi.org/10.1128/AAC.01529-10 en_US
dc.title Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: a comparative study en_US
dc.parent Antimicrobial agents and chemotherapy en_US
dc.journal.volume 55 en_US
dc.journal.number 7 en_US
dc.publocation United States en_US
dc.identifier.startpage 3140 en_US
dc.identifier.endpage 3149 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 105993 en_US
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dc.personcode 110478 en_US
dc.personcode 0000068713 en_US
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dc.personcode 0000068719 en_US
dc.personcode 0000068720 en_US
dc.personcode 105741 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords en_US
dc.staffid en_US
dc.staffid 105741 en_US


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