Growth inhibition of Candida species and Aspergillus fumigatus bystatins

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Show simple item record Macreadie, Ian en_US Johnson, Georgia en_US Schlosser, Tanja en_US Macreadie, Peter en_US
dc.contributor.editor en_US 2012-02-02T08:08:07Z 2012-02-02T08:08:07Z 2006 en_US
dc.identifier 2010001967 en_US
dc.identifier.citation Macreadie Ian et al. 2006, 'Growth inhibition of Candida species and Aspergillus fumigatus bystatins', Elsevier Inc, vol. 262, no. 1, pp. 9-13. en_US
dc.identifier.issn 0378-1097 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy. en_US
dc.language en_US
dc.publisher Elsevier Inc en_US
dc.relation.isbasedon en_US
dc.title Growth inhibition of Candida species and Aspergillus fumigatus bystatins en_US
dc.parent FEMS Microbiology Letters en_US
dc.journal.volume 262 en_US
dc.journal.number 1 en_US
dc.publocation Amsterdam, Netherlands en_US
dc.identifier.startpage 9 en_US
dc.identifier.endpage 13 en_US SCI.Environmental Sciences en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 0000066758 en_US
dc.personcode 0000066786 en_US
dc.personcode 0000066787 en_US
dc.personcode 108249 en_US
dc.percentage 100 en_US Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords antifungal;cholesterol;ergosterol;HMG-CoA reductase inhibition;simvastatin;atorvastatin en_US
dc.staffid en_US
dc.staffid 108249 en_US

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