Substrate specificity of the mitochondrial thioredoxin reductase of the parasitic nematode Haemonchus contortus

Abstract

Thioredoxin reductase (TrxR) is an evolutionary diverse enzyme. In higher eukaryotes, TrxR contains a selenocysteine in the active site which confers high activity and a broad substrate range. The parasitic nematode Haemonchus contortus contains two TrxR