Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

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dc.contributor.author Caine, Jo en_US
dc.contributor.author Sankovich, Sonia en_US
dc.contributor.author Antony, Helma en_US
dc.contributor.author Waddington, Lynne en_US
dc.contributor.author Macreadie, Peter en_US
dc.contributor.author Varghese, Jose en_US
dc.contributor.author Macreadie, Ian en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-02-02T07:15:39Z
dc.date.available 2012-02-02T07:15:39Z
dc.date.issued 2007 en_US
dc.identifier 2010001947 en_US
dc.identifier.citation Caine Jo et al. 2007, 'Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response', Wiley-Blackwell Publishing Ltd., vol. 7, no. 8, pp. 1230-1236. en_US
dc.identifier.issn 1567-1356 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14858
dc.description.abstract The 42 amino acid Alzheimer's A beta peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular A beta, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing A beta exhibited a lower growth yield and a heat shock response, showing that A beta fusions promote stress in cells and supporting the notion that intracellular A beta is a toxic molecule. These studies have relevance in understanding the role of A beta in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by A beta. en_US
dc.language en_US
dc.publisher Wiley-Blackwell Publishing Ltd. en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1567-1364.2007.00285.x en_US
dc.title Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response en_US
dc.parent FEMS Yeast Research en_US
dc.journal.volume 7 en_US
dc.journal.number 8 en_US
dc.publocation United Kingdom, Netherlands en_US
dc.identifier.startpage 1230 en_US
dc.identifier.endpage 1236 en_US
dc.cauo.name SCI.Environmental Sciences en_US
dc.conference Verified OK en_US
dc.for 060500 en_US
dc.personcode 0000066753 en_US
dc.personcode 0000066754 en_US
dc.personcode 0000066755 en_US
dc.personcode 0000066756 en_US
dc.personcode 108249 en_US
dc.personcode 0000066757 en_US
dc.personcode 0000066758 en_US
dc.percentage 100 en_US
dc.classification.name Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Alzheimer?s disease; protein misfolding; heat shock response; Ab; b amyloid; reactive oxygen specie en_US
dc.staffid en_US


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