Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis

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dc.contributor.author Wang, Hua-Jian en_US
dc.contributor.author Wang, Meng en_US
dc.contributor.author Wang, Bing en_US
dc.contributor.author Meng, Xiang-Yu en_US
dc.contributor.author Wang, Yun en_US
dc.contributor.author Li, Ming en_US
dc.contributor.author Feng, Wei-Yue en_US
dc.contributor.author Zhao, Yu-Liang en_US
dc.contributor.author Chai, Zhi-Fang en_US
dc.contributor.editor en_US
dc.date.accessioned 2012-02-02T05:13:10Z
dc.date.available 2012-02-02T05:13:10Z
dc.date.issued 2010 en_US
dc.identifier 2010004271 en_US
dc.identifier.citation Wang Hua-Jian et al. 2010, 'Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis', Royal Society of Chemistry, vol. 25, no. 3, pp. 328-333. en_US
dc.identifier.issn 0267-9477 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/14618
dc.description.abstract A method for quantitative imaging of trace elements in sections of bio-tissues using synchrotron radiation microbeam X-ray fluorescence (SR-?XRF) analysis was developed. The Compton scattering in the SR-?XRFspectrum was utilized as an internal standard to compensate the differences in thickness and density of thin bio-tissue sections. The ratios of element sensitivities to Compton scattering peak obtained from two matrix-matched standard reference materials were used for the calculation of the concentrations of metals in a brain section. The concentrations of Ca, Fe, Cu and Zn in the standard reference material (GBW 08551, pig liver) determined by this method were in good agreement with the certified values. The detection limits of Ca, Fe, Cu and Zn at 2 s detection were 1.15, 0.53, 0.21, and 0.20 ?g g-1, respectively. The method has been successfully applied in accurate and precise imaging of the element variations in the brain section of a transgenic mouse model of Alzheimer's disease. en_US
dc.language en_US
dc.publisher Royal Society of Chemistry en_US
dc.relation.isbasedon http://dx.doi.org/10.1039/b921201a en_US
dc.title Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis en_US
dc.parent Journal of Analytical Atomic Spectrometry en_US
dc.journal.volume 25 en_US
dc.journal.number 3 en_US
dc.publocation Cambridge, UK en_US
dc.identifier.startpage 328 en_US
dc.identifier.endpage 333 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 030100 en_US
dc.personcode 0000068203 en_US
dc.personcode 112014 en_US
dc.personcode 0000068159 en_US
dc.personcode 0000069445 en_US
dc.personcode 0000068210 en_US
dc.personcode 0000068469 en_US
dc.personcode 0000068160 en_US
dc.personcode 0000068185 en_US
dc.personcode 0000068186 en_US
dc.percentage 50 en_US
dc.classification.name Analytical Chemistry en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US


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