Nucleotide-Sequence Analysis Of The Cat Gene Of Proteus-Mirabilis - Comparison With The Type-I (Tn9) Cat Gene

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dc.contributor.author Charles, Ian en_US
dc.contributor.author Keyte, Jw en_US
dc.contributor.author Shaw, Wv en_US
dc.contributor.editor en_US
dc.date.accessioned 2011-02-07T06:24:46Z
dc.date.available 2011-02-07T06:24:46Z
dc.date.issued 1985 en_US
dc.identifier 2009002874 en_US
dc.identifier.citation Charles Ian, Keyte Jw, and Shaw Wv 1985, 'Nucleotide-Sequence Analysis Of The Cat Gene Of Proteus-Mirabilis - Comparison With The Type-I (Tn9) Cat Gene', Amer Soc Microbiology, vol. 164, no. 1, pp. 123-129. en_US
dc.identifier.issn 0021-9193 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/13793
dc.description.abstract In Proteus mirabilis PM13 chloramphenicol resistance is mediated by the cat gene, a single copy of which is present in both resistant and sensitive isolates and which reverts at a high frequency. RNA measurements show an about 8.5-fold increase in cat-specific mRNA in cells expressing the resistance phenotype as compared with those which are sensitive to chloramphenicol. DNA sequence analysis has revealed a high degree of homology between the P. mirabilis cat gene and the type I cat variant (Tn9), 76% at the amino acid level and 73% when nucleotides in the coding sequence are compared. Sequence homology between the strain PM13 cat variant and Tn9 cat was not apparent however in the 5' and 3' flanking regions. Segments of near identity were seen when the upstream sequence of the cat of P. mirabilis was compared with the 5' regions of the Salmonella typhimurium flagellin genes HI and H2, which are alternately expressed by a flip-flop control mechanism involving an invertible promoter and a trans-acting product. en_US
dc.language en_US
dc.publisher Amer Soc Microbiology en_US
dc.relation.isbasedon NA en_US
dc.title Nucleotide-Sequence Analysis Of The Cat Gene Of Proteus-Mirabilis - Comparison With The Type-I (Tn9) Cat Gene en_US
dc.parent Journal Of Bacteriology en_US
dc.journal.volume 164 en_US
dc.journal.number 1 en_US
dc.publocation Washington en_US
dc.identifier.startpage 123 en_US
dc.identifier.endpage 129 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 110800 en_US
dc.personcode 109028 en_US
dc.personcode 0000060129 en_US
dc.personcode 0000060134 en_US
dc.percentage 100 en_US
dc.classification.name Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1985ASA7400018 en_US
dc.description.keywords en_US
dc.staffid en_US


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