Evaluation Of Salmonella-Typhimurium Strains Harboring Defined Mutations In Htra And Aroa In The Murine Salmonellosis Model

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dc.contributor.author Chatfield, Sn en_US
dc.contributor.author Strahan, K en_US
dc.contributor.author Pickard, D en_US
dc.contributor.author Charles, Ian en_US
dc.contributor.author Hormaeche, Ce en_US
dc.contributor.author Dougan, G en_US
dc.contributor.editor en_US
dc.date.accessioned 2011-02-07T06:24:01Z
dc.date.available 2011-02-07T06:24:01Z
dc.date.issued 1992 en_US
dc.identifier 2009002905 en_US
dc.identifier.citation Chatfield Sn et al. 1992, 'Evaluation Of Salmonella-Typhimurium Strains Harboring Defined Mutations In Htra And Aroa In The Murine Salmonellosis Model', Academic Press Ltd, vol. 12, no. 2, pp. 145-151. en_US
dc.identifier.issn 0882-4010 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/13703
dc.description.abstract Derivatives of the mouse-virulent Salmonella typhimurium strain SL1344 were constructed harbouring defined mutations in htrA, aroA or htrA aroA combined. When administered orally or intravenously to BALB/c mice, all the mutants were found to be highly attenuated. All mutants were able to confer significant protection against lethal challenge with SL1344 after a single oral dose of live organisms. SL1344 htrA mutants persisted in livers and spleens at a lower level than SL1344 aroA mutants after intravenous administration. SL1344 htrA aroA mutants persisted at an even lower level and were cleared from the livers and spleens of mice within 21 days of intravenous administration. Thus htrA and htrA aroA mutants can be considered as potential oral vaccines against salmonellosis. en_US
dc.language en_US
dc.publisher Academic Press Ltd en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/0882-4010(92)90117-7 en_US
dc.title Evaluation Of Salmonella-Typhimurium Strains Harboring Defined Mutations In Htra And Aroa In The Murine Salmonellosis Model en_US
dc.parent Microbial Pathogenesis en_US
dc.journal.volume 12 en_US
dc.journal.number 2 en_US
dc.publocation London, UK en_US
dc.identifier.startpage 145 en_US
dc.identifier.endpage 151 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 110800 en_US
dc.personcode 0000060148 en_US
dc.personcode 0000060193 en_US
dc.personcode 0000060143 en_US
dc.personcode 109028 en_US
dc.personcode 0000060157 en_US
dc.personcode 0000060138 en_US
dc.percentage 100 en_US
dc.classification.name Medical Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1992HM96300007 en_US
dc.description.keywords vaccines; Salmonella; mutants; heat-shock en_US
dc.staffid en_US


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