On the biological and genetic diversity in Neospora caninum

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dc.contributor.author Al-Qassab, Sarwat en_US
dc.contributor.author Ellis, John en_US
dc.contributor.author Reichel, Michael en_US
dc.contributor.editor en_US
dc.date.accessioned 2011-02-07T06:21:40Z
dc.date.available 2011-02-07T06:21:40Z
dc.date.issued 2010 en_US
dc.identifier 2009003850 en_US
dc.identifier.citation Al-Qassab Sarwat, Reichel Michael P, and Ellis John 2010, 'On the biological and genetic diversity in Neospora caninum', MDPI Publishing, vol. 2, no. 3, pp. 411-438. en_US
dc.identifier.issn 1424-2818 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/13434
dc.description.abstract Neospora caninum is a parasite regarded a major cause of foetal loss in cattle. A key requirement to an understanding of the epidemiology and pathogenicity of N caninum is knowledge of the biological characteristics of the species and the genetic diversity within it. Due to the broad intermediate host range of the species, worldwide geographical distribution and its capacity fQr sexual reproduction, significant biological and genetic differences might be expected to exist. N caninum has now been isolated from a variety of different host species including dogs and cattle. Although isolates of this parasite show only minor differences in ultrastructure, considerable differences have been reported in pathogenicity using mainly mouse models. At the DNA level, marked levels of polymorphism between isolates were detected in mini- and microsatellites found in the genome of N caninum. Knowledge of what drives the biological differences that have been observed between the various isolates at the molecular level is crucial in aiding our understanding of the epidemiology of this parasite and, in tum, the development of efficacious strategies, such as live vaccines, for controlling its impact. The purpose of this review is to document and discuss for the first time, the nature of the diversity found within the species Neospora caninum. en_US
dc.language en_US
dc.publisher MDPI Publishing en_US
dc.relation.isbasedon http://dx.doi.org/10.3390/d2030411 en_US
dc.title On the biological and genetic diversity in Neospora caninum en_US
dc.parent Diversity en_US
dc.journal.volume 2 en_US
dc.journal.number 3 en_US
dc.publocation Switzerland en_US
dc.identifier.startpage 411 en_US
dc.identifier.endpage 438 en_US
dc.cauo.name SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.for 070708 en_US
dc.personcode 998123 en_US
dc.personcode 910945 en_US
dc.personcode 105509 en_US
dc.percentage 67 en_US
dc.classification.name Veterinary Parasitology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords Diversity; Ultrastructure; Pathogenicity; Antigens; Minisatellites; Microsatellites en_US
dc.staffid en_US
dc.staffid 910945 en_US


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