Delineation Of The Arginine- And Tetrahydrobiopterin-Binding Sites Of Neuronal Nitric Oxide Synthase

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Delineation Of The Arginine- And Tetrahydrobiopterin-Binding Sites Of Neuronal Nitric Oxide Synthase

Boyhan A; Smith David; Charles Ian; Saqi M; Lowe Pn
URI: http://hdl.handle.net/10453/13406
Date: 1997

Abstract:

Nitric oxide synthase (EC 1.14.13.39) catalyses the conversion of arginine, NADPH and oxygen to nitric oxide and citrulline, using haem, (6R)-5,6,7,8-tetrahydro-L-biopterin (tetrahydro-biopterin), calmodulin, FAD and FMN as cofactors. The enzyme consists

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