The Myeloperoxidase-Derived Oxidant Hoscn Inhibits Protein Tyrosine Phosphatases And Modulates Cell Signalling Via The Mitogen-Activated Protein Kinase (Mapk) Pathway In Macrophages

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The Myeloperoxidase-Derived Oxidant Hoscn Inhibits Protein Tyrosine Phosphatases And Modulates Cell Signalling Via The Mitogen-Activated Protein Kinase (Mapk) Pathway In Macrophages

Lane Ae; Tan Jessica; Hawkins Clare; Heather Alison; Davies Michael
URI: http://hdl.handle.net/10453/13404
Date: 2010

Abstract:

MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by hydrogen peroxide to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid) respectively. Specificity constants indicate that SCN- is a majo

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