Peroxiredoxin: a central player in immune modulation.

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dc.contributor.author Robinson, Mark en_US
dc.contributor.author Hutchinson, Andrew en_US
dc.contributor.author Donnelly, Sheila en_US
dc.contributor.author Dalton, John en_US
dc.contributor.editor en_US
dc.date.accessioned 2011-02-07T06:21:08Z
dc.date.available 2011-02-07T06:21:08Z
dc.date.issued 2010 en_US
dc.identifier 2009002606 en_US
dc.identifier.citation Robinson Mark et al. 2010, 'Peroxiredoxin: a central player in immune modulation.', Wiley-Blackwell, vol. 32, no. 5, pp. 305-313. en_US
dc.identifier.issn 0141-9838 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/13376
dc.description.abstract Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts. en_US
dc.language en_US
dc.publisher Wiley-Blackwell en_US
dc.relation.isbasedon http://dx.doi.org/10.1111/j.1365-3024.2010.01201.x en_US
dc.title Peroxiredoxin: a central player in immune modulation. en_US
dc.parent Parasite Immunology en_US
dc.journal.volume 32 en_US
dc.journal.number 5 en_US
dc.publocation Singapore en_US
dc.identifier.startpage 305 en_US
dc.identifier.endpage 313 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 070700 en_US
dc.personcode 100777 en_US
dc.personcode 100527 en_US
dc.personcode 995261 en_US
dc.personcode 030896 en_US
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords helminth;immunomodulation;macrophage;peroxiredoxin en_US
dc.staffid 030896 en_US


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