Sequences Of The Genes And Polypeptide Precursors For 2 Bovine Protease Inhibitors

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dc.contributor.author Creighton, Thomas en_US
dc.contributor.author Charles, Ian en_US
dc.contributor.editor en_US
dc.date.accessioned 2011-02-07T06:21:05Z
dc.date.available 2011-02-07T06:21:05Z
dc.date.issued 1987 en_US
dc.identifier 2009002879 en_US
dc.identifier.citation Creighton Thomas and Charles Ian 1987, 'Sequences Of The Genes And Polypeptide Precursors For 2 Bovine Protease Inhibitors', Academic Press Ltd, vol. 194, no. 1, pp. 11-22. en_US
dc.identifier.issn 0022-2836 en_US
dc.identifier.other C1UNSUBMIT en_US
dc.identifier.uri http://hdl.handle.net/10453/13371
dc.description.abstract The genes for bovine pancreatic trypsin inhibitor and a homologous protease inhibitor have been characterized using messenger RNA, clones of complementary DNA copies and genomic fragments. Both genes consist of three exons and two introns and are virtually identical in sequence, suggesting that recently they either arose by gene duplication or were subject to gene conversion. However, they differ markedly in their promoter regions and in a segment within the first intron. Perhaps as a consequence, the two genes can be expressed using different transcription start sites, and the two proteins are found in different bovine tissues. Each middle exon encodes primarily the mature protein, while the other two exons define amino- and carboxyl-terminal extensions of 33 or 35 and 7 amino acid residues, respectively. The amino-terminal extensions contain a signal peptide-like sequence, suggesting that the proteins are destined for cellular compartments. The remaining extensions at both ends may be involved in targetting of the proteins, and there are some similarities to other proteins destined for cellular compartments. en_US
dc.language en_US
dc.publisher Academic Press Ltd en_US
dc.relation.isbasedon http://dx.doi.org/10.1016/0022-2836(87)90711-X en_US
dc.title Sequences Of The Genes And Polypeptide Precursors For 2 Bovine Protease Inhibitors en_US
dc.parent Journal of Molecular Biology en_US
dc.journal.volume 194 en_US
dc.journal.number 1 en_US
dc.publocation London en_US
dc.identifier.startpage 11 en_US
dc.identifier.endpage 22 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 060100 en_US
dc.personcode 0000061950 en_US
dc.personcode 109028 en_US
dc.percentage 100 en_US
dc.classification.name Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity ISI:A1987G456800002 en_US
dc.description.keywords BPTI, bovine pancreatic trypsin inhibitor (also known as trypsin-kallikrein inhibitor; aprotinin, Trasylol@); SI, spleen inhibitor homologous with BPTI; en_US
dc.staffid en_US
dc.staffid 109028 en_US


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