Nitric Oxide Upregulates Expression Of Dna-Pkcs To Protect Cells From Dna-Damaging Anti-Tumour Agents

Abstract

Nitric-oxide synthase (NOS) activity has been detected in many human tumours, although its function is unclear. Here we show that exposure of cells to nitric oxide (NO) results in a 4-5-fold increase in expression of the DNA-dependent protein-kinase cata