Cysteine-200 Of Human Inducible Nitric Oxide Synthase Is Essential For Dimerization Of Haem Domains And For Binding Of Haem, Nitroarginine And Tetrahydrobiopterin

Abstract

Nitric oxide synthase (EC 1.14.13.39) is a homodimer. Limited proteolysis has previously shown that it consists of two major domains. The C-terminal or reductase domain binds FMN, FAD and NADPH. The N-terminal or oxygenase domain is known to bind arginin