Semisynthesis and Biological Activity of Stemofoline Alkaloids

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Show simple item record Baird, Morwenna en_US Pyne, Stephen en_US Ung, Alison en_US Lie, Wilford en_US Sastraruji, Thanapat en_US Jatisatienr, Araya en_US Jatisatienr, Chaiwat en_US Dheeranupattana, Srisulak en_US Lowlam, Jaturong en_US Boonchalermkit, Sukanya en_US
dc.contributor.editor en_US 2010-06-16T04:57:45Z 2010-06-16T04:57:45Z 2009 en_US
dc.identifier 2008005050 en_US
dc.identifier.citation Baird Morwenna et al. 2009, 'Semisynthesis and Biological Activity of Stemofoline Alkaloids', American Chemical Society, vol. 72, no. 4, pp. 679-684. en_US
dc.identifier.issn 0163-3864 en_US
dc.identifier.other C1 en_US
dc.description.abstract The semisynthesis of the Stemona alkaloids (3?R)-stemofolenol (1), (3?S)-stemofolenol (2), methylstemofoline (3), and (3?S)-hydroxystemofoline (5) and the unnatural analogues (11E)-methylstemofoline (15) and 3?R-hydroxystemofoline (11) has been achieved starting from (11Z)-1?,2?-didehydrostemofoline (4). This synthesis allowed, for the first time, access to diastereomerically enriched samples of 1 and 2 and the assignment of their absolute configurations at C-3?. These compounds were obtained in sufficient quantities to allow for their biological testing. In a quantitative assay as AChE inhibitors, (11Z)-1?,2?-didehydrostemofoline (4) and (3?S)-hydroxystemofoline (5) were found to be the most active. en_US
dc.language en_US
dc.publisher American Chemical Society en_US
dc.relation.isbasedon en_US
dc.title Semisynthesis and Biological Activity of Stemofoline Alkaloids en_US
dc.parent Journal of Natural Products en_US
dc.journal.volume 72 en_US
dc.journal.number 4 en_US
dc.publocation USA en_US
dc.identifier.startpage 679 en_US
dc.identifier.endpage 684 en_US SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 110100 en_US
dc.personcode 0000050256 en_US
dc.personcode 0000061573 en_US
dc.personcode 106546 en_US
dc.personcode 0000050255 en_US
dc.personcode 0000050250 en_US
dc.personcode 0000050251 en_US
dc.personcode 0000050252 en_US
dc.personcode 0000050283 en_US
dc.personcode 0000050284 en_US
dc.personcode 0000050285 en_US
dc.percentage 100 en_US Medicinal and Biomolecular Chemistry en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords NA en_US
dc.staffid en_US

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