Alkaloids from the Roots of Stemona aphylla

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dc.contributor.author Mungkornasawakul, Pitchaya en_US
dc.contributor.author Chaiyong, Sukanda en_US
dc.contributor.author Sastraruji, Thanapat en_US
dc.contributor.author Jatisatienr, Araya en_US
dc.contributor.author Jatisatienr, Chaiwat en_US
dc.contributor.author Pyne, Stephen en_US
dc.contributor.author Ung, Alison en_US
dc.contributor.author Korth, John en_US
dc.contributor.author Lie, Wilford en_US
dc.contributor.editor en_US
dc.date.accessioned 2010-06-16T04:57:45Z
dc.date.available 2010-06-16T04:57:45Z
dc.date.issued 2009 en_US
dc.identifier 2008005017 en_US
dc.identifier.citation Mungkornasawakul Pitchaya et al. 2009, 'Alkaloids from the Roots of Stemona aphylla', American Chemical Society, vol. 72, no. 5, pp. 848-851. en_US
dc.identifier.issn 0163-3864 en_US
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/11792
dc.description.abstract Three known compounds, stemofoline (1), (2'S)-hydroxystemofoline (2), and (11Z)-1',2'-didehydrostemofoline (3), along with two new alkaloids, stemaphylline (4) and stemaphylline-N-oxide (5), have been isolated from a root extract of Stemona aphylla. The structures of these alkaloids were determined on the basis of their spectroscopic data. The analysis of the crude dichloromethane extract by GC-MS in the EIMS mode showed the presence of alkaloids 1-4, the alkaloid 11, and stilbostemin R (12). The crude dichloromethane extract and 4 were tested for their comparative biological activities. The results of their acetylcholinesterase (AChE) inhibitory activities showed that the crude extract had higher activity than that of 4. The insecticidal properties of the crude extract and 4, using a topical application, showed that 4 had an activity similar to the positive control, methomyl, whereas the crude extract had much lower activity. Their antimicrobial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas auruginosa ATCC 27853, and Candida albicans ATCC 90028 was weak (MIC 62.5-125 ?g/mL, MBC 125-250 ?g/mL, MFC 125 ?g/mL) but much higher than that of the crude extract. en_US
dc.language en_US
dc.publisher American Chemical Society en_US
dc.relation.isbasedon http://dx.doi.org/10.1021/np900030y en_US
dc.title Alkaloids from the Roots of Stemona aphylla en_US
dc.parent Journal of Natural Products en_US
dc.journal.volume 72 en_US
dc.journal.number 5 en_US
dc.publocation USA en_US
dc.identifier.startpage 848 en_US
dc.identifier.endpage 851 en_US
dc.cauo.name SCI.Chemistry and Forensic Sciences en_US
dc.conference Verified OK en_US
dc.for 060702 en_US
dc.personcode 0000050248 en_US
dc.personcode 0000050249 en_US
dc.personcode 0000050250 en_US
dc.personcode 0000050251 en_US
dc.personcode 0000050252 en_US
dc.personcode 0000061573 en_US
dc.personcode 106546 en_US
dc.personcode 0000050254 en_US
dc.personcode 0000050255 en_US
dc.percentage 100 en_US
dc.classification.name Plant Cell and Molecular Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords NA en_US


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