Abstract:
Titanium alloy has been used as a material for orthopaedic implants, however drawbacks
still exist. Considerable efforts have been taken to modify the surface structure of the implant
material and improve the biological performance. Previously we have demonstrated that
biomaterials surface modification has a significant effect on the regulation of osteogenesis. We have
investigated the behaviour of human osteoclasts on sol-gel coated carbonated hydroxyapatite on
anodized titanium alloy. Osteoclasts cultured on the modified surface were able to attach and
spread, exhibiting the characteristic peripheral brush border. Successful differentiation of the
monocytes into osteoclasts and their attachment to the coated surface and the formation of
resorption-like imprints indicated that carbonate hydroxyapatite (CHAP) coated titanium alloy play
a significant role in regulating the functional activity of osteoclasts.
