Hypophosphatasia features selective deficiency of activity of the tissue-non-specific (liver/bone/kidney) alkaline phosphatase (ALP) isoenzyme (TNSALP); placental and intestinal ALP isoenzyme (PALP and IALP, respectively) ...
Legler, J.; Lefkopoulou, M; Ryan, Louise(American Statistical Association, 1995)
Global tests provide a useful tool for comparing two or more groups with respect to multiple correlated outcomes. We adapt and compare the performance of tests that have been suggested for use with multiple continuous ...
Goetghebeur, Els; Ryan, Louise(Oxford University Press, 1995)
We propose a method to analyse competing risks survival data when failure types are missing for some individuals. Our approach is based on a standard proportional hazards structure for each of the failure types, and involves ...
Necessary and sufficient global optimality conditions are presented for certain nonconvex minimization problems subject to inequality constraints that are expressed as the pointwise minimum of sublinear (MSL) functions. A ...
Lattice quadrature rules were introduced by Frolov (1977), Sloan (1985) and Sloan and Kachoyan (1987). They are quasi-Monte Carlo rules for the approximation of integrals over the unit cube in R(s) and are generalizations ...
For a graph of m nodes and n edges, an algorithm for testing the isomorphism of graphs is given. The complexity of the algorithm is a maximum of O(mn(2)) in almost all cases, with a considerable reduction if sparsity is ...
We consider the fate of output in the Cournot oligopoly model when the equilibrium is locally unstable. We discuss types of nonlinearities which may be present to bound the motion and introduce time lags in production and ...
This paper investigates two variants of a Keynesian model of monetary growth with sluggish price and quantity adjustments. The first model integrates the real growth dynamics of Rose's employment cycle, an inflationary ...
Virtually all common bandwidth selection algorithms are based on a certain type of kernel functional estimator. Such estimators can be computationally very expensive, so in practice they are often replaced by fast binned ...
We investigate the extension of binning methodology to fast computation of several auxiliary quantities that arise in local polynomial smoothing. Examples include degrees of freedom measures, cross-validation functions, ...
We develop a method for incorporating historical control information into time-adjusted tests for dose effects in carcinogenicity studies. After discretizing the time scale, we use a multinomial distribution to model the ...
Characterizing the dose-effect relationship and estimating acceptable exposure levels are the primary goals of quantitative risk assessment. A semiparametric approach is proposed for risk assessment with continuously ...
We discuss latent variable models that allow for fixed effect covariates, as well as covariates affecting the latent variable directly. Restricted maximum likelihood and maximum likelihood are used to estimate model ...
Goetghebeur and Ryan proposed a method for proportional hazards analyses of competing risks failure-time data when the failure type is missing for some cases. This paper evaluates the properties of the method using data ...
Although many people are exposed to ozone, the effects of chronic exposure to this ubiquitous pollutant, especially low-level chronic exposure, are not well understood. The U.S. Environmental Protection Agency (EPA) current ...
We discuss the design and analysis of studies involving multiple binary outcomes in which only a subset of these outcomes can be measured on each individual. Such studies with "intentionally missing data" may arise due to ...