Browsing by Author "Zamore Pd"

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Browsing by Author "Zamore Pd"

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  • Asymmetry in the assembly of the RNAi enzyme complex 
    Schwarz Ds; Hutvagner Gyorgy; Du T; Xu Zs; Zamore Pd (Cell Press, 2003)
    A key step in RNA interference (RNAi) is assembly of the RISC, the protein-siRNA complex that mediates target RNA cleavage. Here, we show that the two strands of an siRNA duplex are not equally eligible for assembly into ...
  • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA 
    Hutvagner Gyorgy; Mclachlan J; Pasquinelli Ae; Balint E; Tuschl T; Zamore Pd (Amer Assoc Advancement Science, 2001)
    The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster ...
  • Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways 
    Schwarz Ds; Hutvagner Gyorgy; Haley B; Zamore Pd (Cell Press, 2002)
    In Drosophila, two features of small interfering RNA (siRNA) structure-5' phosphates and 3' hydroxyls are reported to be essential for RNA interference (RNAi). Here, we show that as in Drosophila, a 5' phosphate is required ...
  • A microRNA in a multiple-turnover RNAi enzyme complex 
    Hutvagner Gyorgy; Zamore Pd (Amer Assoc Advancement Science, 2002)
    In animals, the double-stranded RNA-specific endonuclease Dicer produces two classes of functionally distinct, tiny RNAs: microRNAs ( miRNAs) and small interfering RNAs (siRNAs). miRNAs regulate mRNA translation, whereas ...
  • RNAi: nature abhors a double-strand 
    Hutvagner Gyorgy; Zamore Pd (Current Biology Ltd, 2002)
    In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation ...
  • Sequence-specific inhibition of small RNA function 
    Hutvagner Gyorgy; Simard Martin; Mello Cc; Zamore Pd (Public Library Science, 2004)
    Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions. Here we ...