Browsing by Author "Zakrzewski Alana"

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Browsing by Author "Zakrzewski Alana"

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  • Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice 
    Miller Catherine; Zakrzewski Alana; Ikin Rowan; Boulter Nicola; Katrib Marilyn; Lees Michael; Fuller Stephen; Wiley James; Smith Narelle (Elsevier Sci Ltd, 2011)
    The P2X(7) receptor (P2X(7)R) is a two transmembrane receptor that is highly expressed on the surface of immune cells. Loss of function polymorphisms in this receptor have been linked to increased susceptibility to ...
  • P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages 
    Lees Michael; Fuller Stephen; Mcleod R; Boulter Nicola; Miller Catherine; Zakrzewski Alana; Mui Ej; Witola William; Coyne Jj; Hargrave Ac; Jamieson S; Blackwell J; Wiley James; Smith Nicholas (American Association of Immunologists, 2011)
    The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. Furthermore, single nucleotide polymorphisms ...
  • The Role of the P2X7 Receptor in Infectious Diseases 
    Miller Catherine; Boulter Nicola; Fuller Stephen; Zakrzewski Alana; Lees Michael; Saunders Bernadette; Wiley James; Smith Nicholas (Plos, 2011)
    ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X7 receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the ...