Browsing by Author "Simpson Pc"

UTSePress Research/Manakin Repository

Search UTSePress Research

Browse

My Account

Browsing by Author "Simpson Pc"

Sort by: Order: Results:

  • Abnormal Myocardial Contraction In Alpha(1A)- And Alpha(1B)-Adrenoceptor Double-Knockout Mice 
    Mccloskey Dt; Turnbull Lynne; Swigart P; O'Connell T; Simpson Pc; Baker Anthony (Academic Press Ltd Elsevier Science Ltd, 2003)
    We used double-knockout mice (ABKO) lacking both predominant myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction. ...
  • Alpha(1)-Adrenergic Receptor Responses In Alpha(1AB)-AR Knockout Mouse Hearts Suggest The Presence Alpha(1D)-AR 
    Turnbull Lynne; Mccloskey Dt; O'Connell T; Simpson Pc; Baker Anthony (Amer Physiological Soc, 2003)
    Two functional (xi-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) have been identified in the mouse heart. However, it is unclear whether the third known subtype, alpha(1D)-AR, is also present. To investigate ...
  • Alpha(1)-Adrenergic Receptors Prevent A Maladaptive Cardiac Response To Pressure Overload 
    O'Connell T; Swigart Pm; Rodrigo Mc; Ishizaka S; Joho S; Turnbull Lynne; Tecott Lh; Baker Anthony; Foster E; Grossman W; Simpson Pc (Amer Soc Clinical Investigation Inc, 2006)
    An alpha(1)-adrenergic receptor (alpha(1)-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result ...
  • Cardiac Transgenesis With The Tetracycline Transactivator Changes Myocardial Function And Gene Expression 
    Mccloskey Dt; Turnbull Lynne; Swigart Pm; Zambon Ac; Turcato S; Joho S; Grossman W; Conklin Br; Simpson Pc; Baker Anthony (Amer Physiological Soc, 2005)
    The cardiac-specific tetracycline-regulated gene expression system (tet-system) is a powerful tool using double-transgenic mice. The cardiac alpha-myosin heavy chain promoter (alpha MHC) drives lifetime expression of a ...
  • Ischemic Preconditioning Depends On Age And Gender 
    Turcato S; Turnbull Lynne; Wang Guan-Ying; Honbo N; Simpson Pc; Karliner Js; Baker Anthony (Dr Dietrich Steinkopff Verlag, 2006)
    The goal of this study was to determine if an ischemic preconditioning (IPC) protocol improved post-ischemic functional recovery of female mouse hearts. A previous study found that IPC did not occur in hearts from 10-week-old ...
  • Sustained Preconditioning Induced By Cardiac Transgenesis With The Tetracycline Transactivator 
    Turnbull Lynne; Zhou Hong; Swigart Pm; Turcato S; Karliner Js; Conklin Br; Simpson Pc; Baker Anthony (Amer Physiological Soc, 2006)
    Preconditioning protocols that protect the heart from ischemic injury may aid in the development of new therapies. However, the temporal window of cardioprotection is limited to a few days after the preconditioning stimulus. ...