Browsing by Author "Pyne, Stephen"

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Browsing by Author "Pyne, Stephen"

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  • Mungkornasawakul, Pitchaya; Chaiyong, Sukanda; Sastraruji, Thanapat; Jatisatienr, Araya; Jatisatienr, Chaiwat; Pyne, Stephen; Ung, Alison; Korth, John; Lie, Wilford (American Chemical Society, 2009)
    Three known compounds, stemofoline (1), (2'S)-hydroxystemofoline (2), and (11Z)-1',2'-didehydrostemofoline (3), along with two new alkaloids, stemaphylline (4) and stemaphylline-N-oxide (5), have been isolated from a root ...
  • Ung, Alison; Pyne, Stephen; Skelton, Brian; White, Allan (Pergamon, 1996)
    A method for preparing the thiazole analogue 2 of the biologically active compound (1R, 2S, 3R)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole 1 is reported.
  • Nichols, Ce; Lamb, Hk; Lockyer, M; Charles, Ian; Pyne, Stephen; Hawkins, Ar; Stammers, Dk (Wiley-Liss, 2007)
    Salmonella typhimurium YegS is a protein conserved in many prokaryotes. Although the function of YegS is not definitively known, it has been annotated as a potential diacylglycerol or sphingosine kinase based on sequence ...
  • Mungkornasawakul, Pitchaya; Matthews, Hayden; Ung, Alison; Pyne, Stephen; Jatisatienr, Araya; Lie, Wilford; Skelton, Brian; White, Allan (Asian Coordinating Group for Chemistry, 2005)
  • Umsumarng, Sonthaya; Pintha, Komsak; Pitchakarn, Pornsiri; Sastraruji, Kwankamol; Sastraruji, Thanapat; Ung, Alison; Jatisatienr, Araya; Pyne, Stephen; Limtrakul, Pornngarm (Pharmaceutical Socety of Japan, 2013)
    Resistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATP-binding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from ...
  • Taylor, Stephen; Ung, Alison; Pyne, Stephen; Skelton, Brian; White, Allan (Pergamon, 2007)
    The oxidative cyclization of 3,4-dimethoxyphenyl 3,4-dimethoxyphenylacetate, through intramolecular biphenyl bond formation, was successful and gave the target seven-membered lactone in good yield (85?86%). All other ester ...
  • Sastraruji, Thanapat; Pyne, Stephen; Ung, Alison (Pergamon, 2012)
    Oxidation of (11Z)-1',2'-didehydrostemofoline with DIB/TBHP/Mg(OAc)(2)center dot 4H(2)O resulted in oxidative cleavage of the C-11-C-12 double bond instead of the desired allylic oxidation of the 1-butenyl side chain. ...
  • Mungkornasawakul, Pitchaya; Pyne, Stephen; Jatisatienr, Araya; Supyen, Damrat; Jatisatienr, Chaiwat; Lie, Wilford; Ung, Alison; Skelton, Brian; White, Allan (American Chemical Society, 2004)
    A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-a]azepine A,B-ring system, and the known pyrrolo[1,2-a]azepine alkaloid oxyprotostemonine (4) have been isolated from a root extract of S. curtisii. ...
  • Chaiyong, Sukanda; Jatisatienr, Araya; Mungkornasawakul, Pitchaya; Sastraruji, Thanapat; Pyne, Stephen; Ung, Alison; Urathamakul, Thitima; Lie, Wilford (American Chemical Society, 2010)
    The isolation of two new Stemona alkaloids, 1-hydroxyprotostemonine and stemocurtisine N-oxide, and a new benzofuran, stemofuran L, from the root extracts of Stemona curtisii is reported. The major known alkaloids from ...
  • Sastraruji, Thanapat; Chaiyong, Sukanda; Jatisatienr, Araya; Pyne, Stephen; Ung, Alison; Lie, Wilford (American Chemical Society, 2011)
    A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2?S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J ...
  • Mungkornasawakul, Pitchaya; Pyne, Stephen; Jatisatienr, Araya; Lie, Wilford; Ung, Alison; Issakul, Kritchaya; Sawatwanich, Auntika; Supyen, Damrat; Jatisatienr, Chaiwat (American Chemical Society, 2004)
    Two new dihydrostemofoline alkaloids, 11(S),12(R)-dihydrostemofoline (3) and stemoburkilline (4), along with stemofoline (1) and 2`-hydroxystemofoline (2) have been isolated from a root extract of Stemona burkillii Prain. ...
  • Sastraruji, Thanapat; Jatisatienr, Araya; Issakul, Kritchaya; Pyne, Stephen; Ung, Alison; Lie, Wilford; Williams, Morwenna (Natural Product Inc., 2006)
    Six new stemofoline alkaloids, (2`R)-hydroxystemofoline (5), (3`R)-stemofolenol (6), (3`S)-stemofolenol (7), 1`,2`-didehydrostemofoline-N-oxide (8), the first C19 stemofoline alkaloid, methylstemofoline (9), and the first ...
  • Sastraruji, Thanapat; Jatisatienr, Araya; Pyne, Stephen; Ung, Alison; Lie, Wilford; Williams, Morwenna (American Chemical Society, 2005)
    Six new stemofoline alkaloids, (2?R)-hydroxystemofoline (5), (3?R)-stemofolenol (6), (3?S)-stemofolenol (7),1?,2?-didehydrostemofoline-N-oxide (8), the first C19 stemofoline alkaloid, methylstemofoline (9), and the first ...
  • Pyne, Stephen; Ung, Alison; Jatisatienr, Araya; Mungkornasawakul, Pitchaya (Maejo University, 2007)
    This paper reviews the isolation, structure elucidation, proposed biosynthesis and biological activities of the small, but increasing, number of pyrido[1,2-a]azepine Stemona alkaloids.
  • Sastraruji, K.; Sastraruji, Thanapat; Pyne, Stephen; Ung, Alison; Jatisatienr, Araya; Lie, W. (American Chemical Society, 2010)
    Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1a??,2a??-didehydrostemofoline (6), which confirmed their structures and absolute configurations. ...
  • Baird, Morwenna; Pyne, Stephen; Ung, Alison; Lie, Wilford; Sastraruji, Thanapat; Jatisatienr, Araya; Jatisatienr, Chaiwat; Dheeranupattana, Srisulak; Lowlam, Jaturong; Boonchalermkit, Sukanya (American Chemical Society, 2009)
    The semisynthesis of the Stemona alkaloids (3?R)-stemofolenol (1), (3?S)-stemofolenol (2), methylstemofoline (3), and (3?S)-hydroxystemofoline (5) and the unnatural analogues (11E)-methylstemofoline (15) and 3?R-hydroxystemofoline ...
  • Mungkornasawakul, Pitchaya; Pyne, Stephen; Jatisatienr, Araya; Supyen, Damrat; Lie, Wilford; Ung, Alison; Skelton, Brian; White, Allan (American Chemical Society, 2003)
    A new pentacyclic stemona alkaloid, stemocurtisine (2), with a novel pyrido[1,2-a]azapine A,B-ring system, has been isolated from a root extract of Stemona curtisii. The structure and relative stereochemistry was determined ...
  • Mungkornasawakul, Pitchaya; Pyne, Stephen; Ung, Alison; Jatisatienr, Araya; Willis, Anne-Marie (Wiley-Blackwell Publishing, Inc, 2009)
    Crystals of the title compound, C22H29NO5 center dot C4H8O2, {[systematic name: (2R,3R,5R,5aS,6R,8aR,9S)-(5Z)-5-[3-butyl-tetrahydro-6-methyl-2,5-methano-4,3,8a-[1]propanyl[3]ylidenefuro[3,2-f][1,4]oxazepin-7(5H)-ylidene] ...
  • Sastraruji, Kwankamol; Pyne, Stephen; Ung, Alison; Mungkornasawakul, Pitchaya; Lie, Wilford; Jatisatienr, Araya (American Chemical Society, 2009)
    Semisynthesis studies starting from (11Z)-1?,2?-didehydrostemofoline (4) indicated that the known Stemona alkaloid stemoburkilline is the Z-isomer and not the E-isomer as initially reported. The semisynthesis involved ...
  • Yong, Sarah; Ung, Alison; Pyne, Stephen; Skelton, Brian; White, Allan (Pergamon, 2007)
    The synthesis of spiro[cyclopropane-1,3?-oxindole]-2-carboxylic acid, including novel 3-(2- and 3-pyridyl)-substituted analogues and the novel cyclopropa[c]quinoline-7b-carboxylic acid and their ester and amide derivatives ...