Browsing by Author "Nizet V"

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Browsing by Author "Nizet V"

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  • Genetic switch to hypervirulence impairs colonization phenotypes of the globally disseminated Group A Streptococcus M1T1 clone 
    Hollands Andrew; Pence M; Timmer A; Osvath Sarah; Turnbull Lynne; Whitchurch Cynthia; Walker Mark; Nizet V (Infectious Diseases Society of America, 2010)
    Background.The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component ...
  • Role of group A Streptococcus HtrA in the maturation of SpeB protease 
    Cole J; Aquilina J; Hains P; Henningham A; Sriprakash K; Caparon M; Nizet V; Kotb M; Cordwell Stuart; Djordjevic Steven; Walker Mark (Wiley - V C H Verlag GmbH & Co. KGaA, 2007)
    The serine protease HtrA (DegP) of the human pathogen Streptococcus pyogenes (group A Streptococcus; GAS) is localized to the ExPortal secretory microdomain and is reportedly essential for the maturation of cysteine protease ...