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Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

Gracanin Michelle; Lam Magdalena; Morgan Philip; Rodgers Kenneth; Hawkins Clare; Davies Michael (Pergamon, 2011)

Proteins are major biological targets for oxidative damage within cells because of their high abundance and rapid rates of reaction with radicals and singlet oxygen. These reactions generate high yields of hydroperoxides. ...
Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteosomal function: Possible links between diabetes and atherosclerosis

Moheimani Fatemeh; Morgan Philip; Van Reyk David; Davies Michael (Elsevier, 2010)

People with diabetes experience chronic hyperglycemia and are at a high risk of developing atherosclerosis and microvascular disease. Reactions of glucose, or aldehydes derived from glucose (e.g. methylglyoxal, glyoxal, ...

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