Browsing by Author "Macreadie, Ian"

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Browsing by Author "Macreadie, Ian"

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  • Caine, Jo; Sankovich, Sonia; Antony, Helma; Waddington, Lynne; Macreadie, Peter; Varghese, Jose; Macreadie, Ian (Wiley-Blackwell Publishing Ltd., 2007)
    The 42 amino acid Alzheimer's A beta peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular A beta, produced through its attachment to either end of a green fluorescent ...
  • Macreadie, Ian; Avery, Thomas; Robinson, Tony; Macreadie, Peter; Barraclough, Miles; Taylor, Dennis; Tiekink, Edward (Pergamon, 2008)
    In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure?activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and ...
  • Avery, Thomas; Macreadie, Peter; Greatrex, Ben; Robinson, Tony; Taylor, Dennis; Macreadie, Ian (Pergamon, 2007)
    Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity ...
  • Macreadie, Ian; Johnson, Georgia; Schlosser, Tanja; Macreadie, Peter (Elsevier Inc, 2006)
    Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two ...
  • Taylor, Dennis; Avery, Thomas; Greatrex, Ben; Tiekink, Edward; Macreadie, Ian; Macreadie, Peter; Humphries, Adam; Kalkanidis, Martha; Fox, Emma; Klonis, Nectarios; Tilley, Leann (American Chemical Society, 2004)
    We report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium ...
  • Macreadie, Peter; Avery, Thomas; Greatrex, Ben; Taylor, Dennis; Macreadie, Ian (Pergamon, 2006)
    A series of novel endoperoxides were synthesised and tested for inhibitory activity against Candida growth. Despite structural similarities, their activity varied considerably. Several endoperoxides demonstrated potential ...