Browsing by Author "Zamore Pd"

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Browsing by Author "Zamore Pd"

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  • A microRNA in a multiple-turnover RNAi enzyme complex 
    Hutvagner Gyorgy; Zamore Pd (Amer Assoc Advancement Science, 2002)
    In animals, the double-stranded RNA-specific endonuclease Dicer produces two classes of functionally distinct, tiny RNAs: microRNAs ( miRNAs) and small interfering RNAs (siRNAs). miRNAs regulate mRNA translation, whereas ...
  • RNAi: nature abhors a double-strand 
    Hutvagner Gyorgy; Zamore Pd (Current Biology Ltd, 2002)
    In organisms as diverse as nematodes, trypanosomes, plants, and fungi, double-stranded RNA triggers the destruction of homologous mRNAs, a phenomenon known as RNA interference. RNA interference begins with the transformation ...
  • Sequence-specific inhibition of small RNA function 
    Hutvagner Gyorgy; Simard Martin; Mello Cc; Zamore Pd (Public Library Science, 2004)
    Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions. Here we ...