Lateral gene transfer has been proposed as a fundamental process underlying bacterial diversity. Transposons, plasmids and phage are widespread and have been shown to significantly contribute to lateral gene transfer. ...

DNA sequencing, phylogenetic and mapping studies suggest that the class 1 integron found in pathogens arose when one member of the diverse family of environmental class 1 integrons became embedded into a Tn402 transposon. ...

Background Gene-directed enzyme prodrug therapy (GDEPT) based on the E. coli enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed ...

Pseudomonas aeruginosa airway infection is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. Various in vitro models have been developed to study P. aeruginosa pathobiology in the CF lung. In ...

Antibiotics were one of the great discoveries of the 20th century. However, resistance appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to become worse, despite the ever-increasing ...

Subspace selection is a powerful tool in data mining. An important subspace method is the Fisherâ¿¿Rao linear discriminant analysis (LDA), which has been successfully applied in many fields such as biometrics, bioinformatics, ...

This paper outlines a generalised boundary solution method for solving flow at boundaries of ID duct models. It is adaptable to duct-duct connections and duct-volume connections with subsonic, choked and supersonic flows. ...

Considering the special characteristics existing in the pulse-width modulated (PWM) switching converter, a general method for the time-stepping finite element analysis based electromagnetic field coupling with its feeding ...